Status:
RECRUITING
Febrile Disease Landscape in Cambodia Via Metagenomic Pathogen Sequencing
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)
Conditions:
Vector-Borne Diseases
Emerging Pathogens
Eligibility:
All Genders
2-65 years
Brief Summary
Background: Vector-borne diseases are caused by the bite of an infected mosquito, fly, flea, tick, or other blood-feeder. These diseases cause almost 1 million deaths per year. And they are on the ri...
Detailed Description
Vector-borne diseases continue to cause significant global morbidity and mortality, particularly in Southeast Asia. However, given a lack of diagnostics available in resource-poor countries, many vect...
Eligibility Criteria
Inclusion
- INCLUSION CRITERIA:
- In order to be eligible to participate in this study, an individual must meet all of the following criteria:
- Provision of signed and dated informed consent form.
- Stated willingness to comply with all study procedures.
- Male or female, aged 2 months to 65 years.
- Meets one of the following case definitions:
- Febrile patient: has documented fever equal to or greater than 38 degrees celsius in previous 24 hours.
- Red flag patient: is an individual with disease relating to a red flag pathogen (see list, below), with confirmed standard laboratory testing (e.g., blood culture, polymerase chain reaction \[PCR\]) for the pathogen in question.
- Afebrile close contact: is an afebrile individual who lived in the same household or worked in the same enclosed workspace on a daily basis with a red flag patient at the time they got sick with a known pathogen.
- Willing to allow biological samples to be stored for future research and for all de-identified metagenomic sequencing data to be stored in publicly accessible databases.
- EXCLUSION CRITERIA:
- Any underlying, chronic, or current medical condition that, in the opinion of the investigator, would interfere with participation in the study (e.g., inability or great difficulty in drawing blood).
- Any febrile individual who has had surgery in the prior month.
- Any patient who enrolled and exited this study within 30 days of the initial study blood draw, or afebrile close contact who enrolled and exited within 14 days.
Exclusion
Key Trial Info
Start Date :
July 23 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2026
Estimated Enrollment :
6500 Patients enrolled
Trial Details
Trial ID
NCT04034264
Start Date
July 23 2019
End Date
July 1 2026
Last Update
December 31 2025
Active Locations (6)
Enter a location and click search to find clinical trials sorted by distance.
1
Kampong Speu Referral Hospital
Chbar Mon, Cambodia
2
Kantha Bopha Hospital
Phnom Penh, Cambodia
3
Khmer-Soviet Friendship Hospital
Phnom Penh, Cambodia
4
National Pediatric Hospital
Phnom Penh, Cambodia