Status:
COMPLETED
Local Minocycline in Patients Under Supportive Periodontal Therapy
Lead Sponsor:
National Dental Centre, Singapore
Conditions:
Periodontitis
Eligibility:
All Genders
21-90 years
Phase:
PHASE4
Brief Summary
The aims of the present study are to assess the significance of the adjunctive effect of the subgingival application of a 2% minocycline hydrochloride controlled-delivery system (MHS) in comparison to...
Detailed Description
It has been reported that regular maintenance of subjects with treated periodontal disease is the key consideration in the long-term periodontal prognosis of these subjects. Periodic prophylaxis may p...
Eligibility Criteria
Inclusion
- Medically healthy adults (ASA classification I-II)
- At least 21 years of age.
- Previously diagnosed with moderate to severe periodontitis and had completed at least 1 round of periodontal therapy including scaling and root-planing, oral hygiene instructions.
- Treated periodontitis patients undergoing maintenance care for at least 6 months.
- Ability to comply with 12-month study follow-up.
- Recurrent moderate to severe periodontitis with no previous systemic antibiotic therapy during initial periodontal therapy.
- At least 4 teeth present with residual PPD of ≥ 5 mm on each and a positive bleeding on probing (BOP).
Exclusion
- Medically compromised subjects (ASA classification III-V).
- Known allergy or other severe adverse reactions to minocycline and related drugs.
- Patients who reported local and/or systemic antibiotic therapy within 3 months prior to baseline examination of the study, and were placed on antibiotics during active initial periodontal therapy.
- Patients with a plaque control record \> 30%.
- Patients who had history of surgical periodontal treatment less than 5 years in the area with lesions.
- Pregnant or intend to conceive or are breast feeding.
Key Trial Info
Start Date :
June 3 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 18 2019
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT04036890
Start Date
June 3 2016
End Date
October 18 2019
Last Update
December 2 2019
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.