Status:
RECRUITING
Ischemic Conditioning Improves Walking Function Post Stroke
Lead Sponsor:
Medical College of Wisconsin
Collaborating Sponsors:
Marquette University
Conditions:
Stroke
Stroke, Ischemic
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
This innovative study will address scientific and clinical areas relatively unexplored in chronic stroke that could lead to greater recovery of walking. Ischemic Conditioning (IC) is a non-invasive, s...
Detailed Description
This study will quantify the effects of Ischemic Conditioning and treadmill training on improvements in: walking speed, leg strength, neuromuscular fatigability and the hyperemic blood flow response t...
Eligibility Criteria
Inclusion
- Inclusion Criteria (Stroke Survivors):
- be ≥ 1 year post diagnosis of a unilateral, cortical stroke and have residual lower extremity paresis
- be between the ages of 18-85
- be able to give informed consent
- walk slower than normative values based on age and sex
- Exclusion Criteria (Stroke Survivors):
- history of deep vein thrombosis or any condition in which transient ischemia to the lower extremity is contraindicated
- inability to follow 2 step commands
- chronic low back or hip pain
- history of substance abuse
- history of head trauma
- comorbid neurological disorder
- any uncontrolled medical condition
- pacemaker
- any condition where fatiguing contractions or resisted leg contractions are contraindicated
- inability to walk for 5 minute bouts on a treadmill with a harness supporting up to 50% of the body weight at 80% of over-ground self-selected walking speed.
- Inclusion Criteria (Healthy Control Subjects):
- be between ages of 18-85
- be able to give informed consent
- Exclusion Criteria (Healthy Control Subjects):
- Those listed above for stroke survivors
- History of Stroke
Exclusion
Key Trial Info
Start Date :
December 20 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT04038697
Start Date
December 20 2018
End Date
June 30 2026
Last Update
April 25 2025
Active Locations (2)
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1
Medical College of Wisconsin
Milwaukee, Wisconsin, United States, 53226
2
Marquette University
Milwaukee, Wisconsin, United States, 53233