Status:
COMPLETED
Tai Chi for Knee OA Pain Management: a Mechanistic Study
Lead Sponsor:
Texas Tech University Health Sciences Center
Conditions:
Knee Osteoarthritis
Mind-body Exercise
Eligibility:
FEMALE
Phase:
NA
Brief Summary
This study is to determine how 8-week Tai Chi intervention alters plasma endocannabinoid and its receptors in monocytes/marcrophages, plasma oxylipinds, plasma brain-derived neurotrophic factor, brain...
Detailed Description
Knee osteoarthritis (OA) is one of the five leading causes of disability. Previous studies have shown that a mind-body moderate-intensity Tai Chi (TC) exercise (8-24 weeks) reduced pain and improved p...
Eligibility Criteria
Inclusion
- Postmenopausal women.
- WOMAC pain score ≥ 50 on at least 1 of the 5 questions in pain subscale (range of 0 to 100, with higher scores indicating greater pain.
- English literacy.
- Able to undergo an MRI scan
- Diagnosed Have the following symptoms associated with knee OA based on American College of Rheumatology clinical classification criteria for osteoarthritis (Peat 2006). Pain in the knee. Need to at least 3 of the following: over 50 years of age, less than 30 minutes of morning stiffness, crepitus on active motion, bony tenderness, bony enlargement, or no palpable warmth of synovium.
Exclusion
- Prior experience with mind-body practice (e.g. TC, Qi Gong, yoga, or acupuncture) or physical therapy programs for knee OA within the past 3 months.
- Severe medical limitations (i.e., dementia, symptomatic heart or vascular disease, or recent stroke) precluding full participation.
- Medical/neurologic or other systemic diseases affecting the musculoskeletal systems (i.e. polio/Parkinson's/multiple sclerosis, etc. in addition to cerebral vascular accident or stroke) and diabetes with peripheral neuropathy affecting their sensory/balance.
- Intra-articular steroid injection or reconstructive surgery on most severely affected knee in the past three months.
- Intra-articular hyaluronic acid injections on most severely affected knee in the past six months.
- Inability to walk without an assistive device.
Key Trial Info
Start Date :
September 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2024
Estimated Enrollment :
33 Patients enrolled
Trial Details
Trial ID
NCT04046003
Start Date
September 1 2019
End Date
August 31 2024
Last Update
March 28 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Texas Tech University Health Sciences Center
Lubbock, Texas, United States, 79430