Status:
RECRUITING
Impact of Treating Severe Periodontitis on Inflammatory Activity of Atheromatous Plaques in Patients With Acute Myocardial Infarction (AMI)
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
National Research Agency, France
Conditions:
Acute Myocardial Infarction
Severe Periodontitis
Eligibility:
All Genders
30-70 years
Phase:
NA
Brief Summary
Multicenter randomized clinical trial with two arms in patients hospitalized for an AMI nested in the Frenchie registry. Periodontal therapy is performed by periodontists in the intervention group ver...
Detailed Description
Eligible adults 30 to 70 years old hospitalized for an MI, (cf inclusion and non-inclusion criteria), will be asked to participate in the study. (screening) At M0 : * patients will be examined by a ...
Eligibility Criteria
Inclusion
- Patients hospitalized for an acute myocardial infarction and included in the Frenchie registry
- Score ≥ 5 on the screening questionnaire for periodontitis
- Six teeth at least (excluding wisdom teeth)
- Consent signature
- Affiliation to a French medical insurance (Sécurité Sociale)
Exclusion
- Patients with diseases,other than cardiovascular and diabetes, known to change the periodontal state such as AIDS, rheumatoid arthritis, Chediak-Higashi syndrome, Papillon-Lefèvre
- Systemic antibiotic therapy\> 48 hours in the 3 months prior to inclusion
- Acute heart failure
- Uncontrolled ventricular rhythm disorders
- Impossibility for the patient to attend follow-up visits
- Impossibility to maintain the extended position for 20 minutes
- Immunosuppressive therapy\> 1 month in the 6 months prior to inclusion
- Pregnancy, breastfeeding
- Known hypersensitivity to chlorhexidine, povidone, 18-fluoro-deoxyglucose
Key Trial Info
Start Date :
August 2 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2028
Estimated Enrollment :
210 Patients enrolled
Trial Details
Trial ID
NCT04046237
Start Date
August 2 2019
End Date
August 1 2028
Last Update
September 8 2025
Active Locations (1)
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1
Hôpital Bichat, AP-HP
Paris, France