Status:
RECRUITING
Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
National Cancer Institute (NCI)
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions:
Glioma
Glioblastoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This clinical trial evaluates the use of microdialysis catheters during surgery to collect biomarkers, and studies the feasibility of intraoperative microdialysis during neurosurgery for central nervo...
Detailed Description
PRIMARY OBJECTIVE: I. Determine biomarkers of in situ gliomas across a diverse patient cohort using intra-operative microdialysis to sample extracellular metabolites. SECONDARY OBJECTIVE: I. Evalua...
Eligibility Criteria
Inclusion
- Age \>= 18 years
- Diagnosis of the following, based on clinical and radiographic evidence:
- Any glioma
- Metastatic brain tumor of any primary origin
- Epileptic focus requiring surgical resection
- Planned neurosurgical procedure for purposes of biopsy or resection of suspected or previously diagnosed brain tumor (primary or metastatic) or epileptic focus as part of routine clinical care
- Willing to undergo neurosurgical resection or biopsy at Mayo Clinic (Rochester, Minnesota \[MN\])
- Ability to understand and the willingness to sign a written informed consent document
Exclusion
- Vulnerable populations: pregnant women, prisoners or the mentally handicapped
- Patients who are not appropriate candidates for surgery due to current or past medical history or uncontrolled concurrent illness
Key Trial Info
Start Date :
January 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2027
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04047264
Start Date
January 1 2020
End Date
September 1 2027
Last Update
September 11 2025
Active Locations (1)
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1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905