Status:
COMPLETED
The Occurrence of Single Nucleotide Polymorphism Among Women Who Experienced Obstetric Anal Sphincter Injury
Lead Sponsor:
HaEmek Medical Center, Israel
Conditions:
Delivery, Obstetric
Eligibility:
FEMALE
18-60 years
Phase:
NA
Brief Summary
Single-nucleotide polymorphisms (SNP's) in connective tissue components are associated with increased risk of pelvic organ prolapse (POP). The investigators expect to find a difference in SNP's freque...
Detailed Description
The perineum consists of skin, muscles and connective tissue. A connective tissue disorder related to POP has been reported in biochemical and molecular studies. OASIS are considered a severe complica...
Eligibility Criteria
Inclusion
- Women with severe external anal sphincter injury during first vaginal delivery
- Healthy women undergoing vaginal delivery without any clinically apparent perineal laceration
Exclusion
- Women with known metabolic or connective-tissue disorder (e.g., Ehlers-Danlos syndrome).
- Women with known neurologic disorder
- Women undergoing episiotomy cut or assisted delivery (e.g., vacuum or forceps delivery)
Key Trial Info
Start Date :
September 4 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 5 2023
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT04047433
Start Date
September 4 2020
End Date
October 5 2023
Last Update
March 26 2025
Active Locations (1)
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1
Haemek Medical Center
Afula, Israel, Israel