Status:
COMPLETED
Respiratory Control and Narcotic Effects
Lead Sponsor:
Duke University
Conditions:
Ventilatory Depression
Opioid Intoxication
Eligibility:
All Genders
18+ years
Brief Summary
The aim of this study is to provide data that will assess the role of ventilatory chemosensitivity (respiratory drive) in determining postoperative respiratory depression due to opioids. In a group of...
Detailed Description
The study aims to test the following hypotheses: Low respiratory drive is predictive of opioid-induced respiratory depression as defined by end-tidal PCO2 (PETCO2) \>50 mmHg, ventilation \<20% below ...
Eligibility Criteria
Inclusion
- 18 years of age or older, undergoing major abdominal or urological surgery requiring at least one overnight hospital stay
Exclusion
- Pregnancy Adverse reaction to remifentanil Opioid-use within the past month Dependency on supplemental oxygen Brain injury in the past year Coronary artery disease Sickle cell disease.
Key Trial Info
Start Date :
March 8 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 9 2019
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04047550
Start Date
March 8 2018
End Date
February 9 2019
Last Update
August 27 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Duke University Medical Center
Durham, North Carolina, United States, 27710