Status:
UNKNOWN
Computer-aided and Mental Trainings Induced Plasticity of Sensorimotor Cortex in Patients Born Without Upper Limbs
Lead Sponsor:
Wroclaw University of Health and Sport Sciences
Collaborating Sponsors:
Wrocław University of Science and Technology
Kessler Foundation
Conditions:
Amelia of Upper Limb
Eligibility:
All Genders
18-25 years
Phase:
NA
Brief Summary
This project will explore a potentially powerful trainings that may be administered before upper extremity transplantation to induced plasticity of sensorimotor cortex in humans with congenital absenc...
Detailed Description
This project will explore a potentially powerful trainings that may be administered before upper extremity transplantation to induced plasticity of sensorimotor cortex in humans with congenital absenc...
Eligibility Criteria
Inclusion
- Inclusion Criteria for patients:
- Age between 18 and 25 years
- Health status: bilateral upper limb congenital transverse deficiency individuals. Subjects must be free from neurological impairment. The subjects must have no current or past history of central or peripheral nervous system dysfunction, be taking no current medication known to affect the neuromuscular system, have no greater than moderate consumption of alcohol or caffeine, and be able to remain seated for 1 hour 30 min and lay supine without moving for 30 min (MRI test). All recruited subjects will be interviewed and their health status and medical history will be evaluated by a medical practitioner qualified to practice surgery and transplant surgery.
- Training history: Subjects not participating in any type of training program in the last 5 years
- Right Hemispheric Dominance. We will use Foot Dominance test - Observation of our subjects to see which foot they use to kick a ball, step up onto a stair, and step onto a coin placed on the floor.
- Availability and interest: All candidates for the study must be available for the familiarization, training, and testing sessions and must have transportation to these sessions.
- Exclusion Criteria for patients:
- Presence of neurological impairment (history of central or peripheral nervous system dysfunction)
- Taking medication that affects the neuromuscular system
- Left hemispheric dominance
- Participation in training over the last five years
- Inclusion Criteria for control subjects:
- Age between 18 and 25 years
- Health status: subjects must be free from neurological and neuromuscular system impairment. The subjects must have no current or past history of central or peripheral nervous system dysfunction, be taking no current medication known to affect the neuromuscular system, have no greater than moderate consumption of alcohol or caffeine, and be able to remain seated for 1 hour 30 min and lay supine without moving for 30 min (MRI test). ). All recruited subjects will be interviewed and their health status and medical history evaluated by neurologist.
- Training history: subjects not participating in any type of training program in the last 5 years.
- Hemispheric Dominance -right. We will use The Edinburgh inventory (Oldfield, 1971) and Foot Dominance test.
- Availability and interest - All subjects for the study must be available for the familiarization, training, and testing sessions and must have transportation to these sessions.
- Exclusion Criteria for control subjects:
- Presence of neurological impairment (history of central or peripheral nervous system dysfunction)
- Taking medication that affects the neuromuscular system
- Left hemispheric dominance
- Participation in training over the last five years
Exclusion
Key Trial Info
Start Date :
March 11 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT04048083
Start Date
March 11 2014
End Date
December 1 2019
Last Update
August 7 2019
Active Locations (1)
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1
University School of Physical Education in Wroclaw
Wroclaw, Lower Silesian Voivodeship, Poland, 51 612