Status:
UNKNOWN
Mastication and Energy Expenditure in Normal Weight and Obese People
Lead Sponsor:
University Hospital, Clermont-Ferrand
Collaborating Sponsors:
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Centre de Recherche en Odontologie Clinique (CROC), Faculté Dentaire
Conditions:
Nutrition
Mastication
Eligibility:
MALE
20-30 years
Phase:
NA
Brief Summary
The objective of the study is to analyze the specific role of physical properties of food and mastication in the cephalic phase reflex of thermogenesis, and the involvement of the autonomic nervous sy...
Detailed Description
A group of 12 subjects presenting a normal weight and a group of 12 obese subjects, with a good general health and a good dental state will be constituted. They will participate to 5 different recordi...
Eligibility Criteria
Inclusion
- Inclusion criteria :
- 19 \< body mass index \< 25 kg/m2 for the normal weight group 30 \< body mass index \< 35 kg/m2 for the obese group Good general health
- Exclusion criteria :
- sport activity
- Smoking in the 6 months before the beginning of the study
- Regular alcohol consumption (more than 4 unit/day)
- Medication that may interfere with the results of the study (beta-blockers, corticoids, anti-inflammatories, thyroid hormone, insulin, antiarrhythmics) or that may have an effect on salivation or muscular activity
- Oral or dental pathology (including pain), current oral care
- Orthodontic treatment in the 3 years before the study
- Weigh gain or weight loss of more than 10% in the 3 last months
- Thyroid disturbance
- High blood pressure
- Cardiac activity anomaly
- Anomaly for one of the biological elements : complete blood count, fasting blood glucose, glycated haemoglobin, thyroid hormone (TSH), sedimentation rate \> 8mm, CRP rate \> 10ml/L
- Allergies, intolerance or disgust for one of the food tested
Exclusion
Key Trial Info
Start Date :
December 5 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04050930
Start Date
December 5 2018
End Date
December 1 2020
Last Update
August 9 2019
Active Locations (1)
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1
CHU de Clermont-Ferrand
Clermont-Ferrand, Auvergne, France, 63003