Status:
TERMINATED
Exercise Training and Metabolic Flexibility in Prediabetes
Lead Sponsor:
Wake Forest University Health Sciences
Conditions:
PreDiabetes
Sedentary Lifestyle
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
The purpose of the study is to determine if a 6-week exercise training program promotes exercise-induced metabolic flexibility, that is, the ability to switch fuel sources for energy, in older prediab...
Detailed Description
This is an investigator initiated single group intervention trial. All participants will receive a 6-week exercise training program with testing occurring before and following the training program. Pa...
Eligibility Criteria
Inclusion
- ≥60 years of age
- Sedentary prior to the start of the training program (self-reported: less than 30 minutes of exercise for no more than 1 day a week)
- Prediabetes (measured at first screening: HbA1c = 5.7-6.5%)
- Must be able to pick-up and consume study provided foods
- Willingness to provide informed consent and participate in the intervention
- Must obtain transportation to visits and intervention training sessions
- No contraindications for involvement in a moderate exercise training program or exercise testing procedures by self-report
Exclusion
- Self-reported diagnosis of a metabolic or chronic disease such as cardiovascular disease, diabetes, Chronic Obstructive Pulmonary Disease, or movement disorders such as Parkinson's disease, Ataxia, Huntington's Disease
- Current or recent (\<12 months) treatment for cancer
- Body Mass Index \<18.5 or \>/30.0 kg/m2
- Tobacco users
- Febrile or chronic infection within study period
- Aversion to testing procedures
- Hypertension, hyperthyroidism, hypothyroidism
- Unwilling to abstain from ingesting caffeine during study testing periods
- Unwilling to withhold medications that affect metabolic rate during testing periods
- Physically active (\>30 minutes per day on more than 1 day per week)
- ECGs that indicate cardiac injury or contraindications to treadmill testing
- Allergic or intolerant to any study-provided foods
Key Trial Info
Start Date :
October 29 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 17 2022
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT04051229
Start Date
October 29 2019
End Date
August 17 2022
Last Update
November 7 2023
Active Locations (2)
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1
Department of Health and Exercise Science Clinical Research Center
Winston-Salem, North Carolina, United States, 27105
2
Wake Forest Baptist Medical Center Clinical Research Unit
Winston-Salem, North Carolina, United States, 27157