Status:
UNKNOWN
P. Falciparum Infection Dynamics and Transmission to Inform Elimination
Lead Sponsor:
London School of Hygiene and Tropical Medicine
Collaborating Sponsors:
Medical Research Council Unit, The Gambia
National Malaria Control Programme, The Gambia
Conditions:
Malaria
Eligibility:
All Genders
6+ years
Phase:
NA
Brief Summary
In the current study, three experimental approaches aiming at reducing malaria transmission will be tested. The study will cover two transmission season (2019 and 2020) and the interventions will vary...
Detailed Description
In the current study, the investigators will first improve access to care in all villages by implementing community-based clinical case management (CCM) (year 1). In this year, the investigators will ...
Eligibility Criteria
Inclusion
- Resident in the village.
- Willingness to participate in repeated assessments of health and infection status and to donate a maximum of 30 mL (milliliter) of blood (children \<5 years of age), 37 mL (milliliter) of blood (children \<10 years of age) or 52 mL (milliliter) of blood (older individuals) during an 18-month period.
Exclusion
- Any chronic illness that would affect study participation.
- Pre-existing severe chronic health conditions
- History of intolerance to artemether-lumefantrine.
- Participants \< 6months old and pregnant women in the first trimester (only for Arm with MDA-DP treatment).
- Hypersensitivity to DP (only for Arm with MDA-DP treatment).
- Taking drugs that influence cardiac function or prolong QTcorrected interval (only for Arm with MDA-DP treatment).
Key Trial Info
Start Date :
August 15 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 31 2022
Estimated Enrollment :
4000 Patients enrolled
Trial Details
Trial ID
NCT04053907
Start Date
August 15 2019
End Date
May 31 2022
Last Update
March 31 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Medical research Council Unit The Gambia at LSHTM
Basse Santa Su, The Gambia