Status:
ENROLLING_BY_INVITATION
Bright Light Therapy for Sleep Disturbance in People With Multiple Sclerosis
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute on Minority Health and Health Disparities (NIMHD)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Sleep disturbance is common in people with multiple sclerosis (MS) and contributes to diminished quality of life. Bright light therapy may be an innovative strategy to reduce sleep disturbance in MS, ...
Detailed Description
Multiple sclerosis (MS), an inflammatory and neurodegenerative disorder of the central nervous system (CNS), is the most common cause of progressive neurologic dysfunction in early to middle adulthood...
Eligibility Criteria
Inclusion
- Diagnosis of MS
- Evidence of sleep disturbance
- Stable on immunomodulatory MS therapy or no therapy for at least 6 months prior to study initiation
- Stable on antidepressants for at least 3 months prior to study initiation and no evidence
- Stable on fatigue medication for at least 3 months prior to study initiation
- Willing and able to provide informed consent and follow study procedures.
Exclusion
- Evidence of cognitive impairment
- Low risk for sleep disordered breathing
- Other comorbid ophthalmologic disorders (e.g. cataracts, glaucoma, blindness)
- Traveled across two time zones within 90 days of study screening.
- Not participating in shift work
- MS relapse or history of acute optic neuritis within 30 days
- No prior history of bipolar disorder
- No evidence of current depression
- Diagnosis of severe periodic limb movement disorder or severe restless legs syndrome
Key Trial Info
Start Date :
February 22 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 30 2026
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04054050
Start Date
February 22 2021
End Date
January 30 2026
Last Update
February 3 2025
Active Locations (1)
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1
Johns Hopkins School of Medicine
Baltimore, Maryland, United States, 21287