Status:
COMPLETED
Influence of rTMS on Symptoms and Cognitive Function in Patients With Psychiatric Disorders
Lead Sponsor:
Beijing HuiLongGuan Hospital
Conditions:
Schizophrenia
Major Depressive Disorder
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
The investigators investigated the effects of high frequency (10Hz) repetitive transcranial magnetic stimulation (rTMS) on the symptoms and cognitive functioning in patients with psychiatric disorders
Detailed Description
OBJECTIVE: This study aimed to evaluate the efficacy of high-frequency rTMS over left dorsolateral prefrontal cortex in the treatment of symptoms and cognitive functioning in 200 chronic patients with...
Eligibility Criteria
Inclusion
- For Schizophrenia Patients:
- Diagnosis of schizophrenia by two senior psychiatrists
- Between 18 and 60 years and Han Chinese
- Duration of symptoms at least 12 months
- With unresolved negative symptoms (Negative scale of PANSS ≥20 and positive scale of PANSS \< 24)
- Smoking
- For Major Depressive Disorder Patients:
- Diagnosis of Major depressive disorder by two senior psychiatrists
- Between 18 and 60 years and Han Chinese
- Duration of symptoms at least 12 months
- Smoking
Exclusion
- Documented disease of physical diseases including, but not limited to seizure, epilepsy, aneurysm brain tumor, and stroke, dementia, parkinson's disease, Huntington's disease, multiple sclerosis
- Acute, unstable and/or significant and untreated medical illness (e.g., infection, unstable diabetes, uncontrolled hypertension)
- Severe headache for unknown reasons and cardiovascular diseases, intracranial metals, pacemakers, severe and those receiving electroconvulsive therapy in the past 3 months
- Past history of autoimmune and allergies, hypertension, lung disease, diabetes or cerebrovascular disease), past history of neurological illness (head trauma with loss of consciousness for more than 5 minutes) or family history of epilepsy increasing the risk of seizures
- Education level less than 5 years by subject report
- Receiving or planning to start the psychotherapy during the rTMS treatment or past received psychotherapy 6 months before the current study
- Subjects who suffered from alcohol or illegal drug abuse/dependence
Key Trial Info
Start Date :
December 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 30 2020
Estimated Enrollment :
800 Patients enrolled
Trial Details
Trial ID
NCT04055181
Start Date
December 1 2018
End Date
January 30 2020
Last Update
June 9 2021
Active Locations (6)
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1
Chaohu Hospital of Anhui medical unviersity
Chaohu, Anhui, China, 238000
2
Zhongshan Third People's Hospital
Zhongshan, Guangdong, China, 528400
3
Wuhan Mental Health Center
Wuhan, Hubei, China, 100096
4
Ganzhou Third Hospital
Ganzhou, Jiangxi, China, 341000