Status:
COMPLETED
Brain Imaging in Tobacco Smokers During a Quit Attempt
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Tobacco Use Disorder
Tobacco Smoking
Eligibility:
All Genders
21-50 years
Phase:
PHASE1
Brief Summary
The proposed study will help fill gaps in existing research by determining if nicotine-dependent cigarette smokers show changes in α7 nicotinic acetylcholine receptor (nAChR) availability when compare...
Detailed Description
The primary objective of this basic clinical research study is to examine the role of the alpha7-nicotinic acetylcholine receptors (nAChRs) in tobacco use disorder. nAChRs are the primary site of acti...
Eligibility Criteria
Inclusion
- Subjects must be healthy volunteers
- Regular tobacco smokers for a period of 2 or more years
- Positive breath carbon monoxide (CO)
- Cotinine positive urine test
- Meet DSM-V criteria for tobacco use disorder.
Exclusion
- Meets DSM-5 criteria for alcohol use disorder or substance use disorder (excluding tobacco use disorder)
- Meets DSM-5 Psychiatric Disorder; in or in need of treatment
- History of seizures, seizure disorder or closed head trauma
- HIV positive
- Weight \> 350 lbs
- \< 5th grade reading level
- Recent use of smoking cessation products
- If female: pregnant, lactating, planning pregnancy; positive urine pregnancy screen
- Any condition which would preclude MRI
- Radiation exposure in the last year that when combined with the study protocol would exceed the annual limits.
Key Trial Info
Start Date :
December 16 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 30 2022
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT04055467
Start Date
December 16 2019
End Date
November 30 2022
Last Update
August 6 2024
Active Locations (1)
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1
Elise Weerts
Baltimore, Maryland, United States, 21224