Status:
COMPLETED
Comparison of High-dose Rosuvastatin Versus Low-dose Rosuvastatin Plus Ezetimibe on Carotid Plaque Inflammation in Patients With Acute Coronary Syndrome
Lead Sponsor:
Yuhan Corporation
Conditions:
Acute Coronary Syndrome
Carotid Atherosclerotic Plaque With Inflammation
Eligibility:
All Genders
19+ years
Phase:
PHASE4
Brief Summary
Combination therapy of ezetimibe with a low-dose statin is occasionally used to avoid statin-related side effects in clinical practice among patients with atherosclerotic cardiovascular disease. This ...
Eligibility Criteria
Inclusion
- aged ≥ 19 years
- acute coronary syndrome, carotid artery disease (diameter stenosis 20-50%), and at least one 18FDG uptake lesion in the carotid artery (target to background ratio (TBR) ≥ 1.6) by 18FDG PET/CT imaging
- written consent
Exclusion
- previous history of carotid endarterectomy or stenting
- schedule for cardiac or major surgery within the next 6 months
- statin or ezetimibe therapy in the past 4 weeks
- chronic disease needed to be treated with oral, intravenous, or intraarticular steroid
- end-stage renal disease
- chronic liver disease
- history of cancers within the past 3 years
- pregnant, breast-feeding or child-bearing potential
- expected life expectancy within 2 years
Key Trial Info
Start Date :
June 29 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 23 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT04056169
Start Date
June 29 2017
End Date
July 23 2019
Last Update
August 16 2019
Active Locations (2)
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1
Asan Medical Center
Seoul, South Korea
2
Korea University Guro Hospital
Seoul, South Korea