Status:
WITHDRAWN
Water Homeostasis in Propofol Based Total Intravenous Anesthesia
Lead Sponsor:
Gangnam Severance Hospital
Conditions:
Spine Surgery With Neuromonitoring
Eligibility:
All Genders
20-70 years
Brief Summary
Previous study reported that propofol binded to glutamate receptors in the hypothalamus and inhibits AVP release mediated by endogenous γ-aminobutyric acid, as well as directly inhibits the regulated ...
Detailed Description
"All patients will get the total intravenous anesthesia with propofol-remifentanil via an effective site-controlled infusion (TCI). For this, TCI continuous infusion pump will be used with Schnider ph...
Eligibility Criteria
Inclusion
- Patients, ASA Classification I-Ⅲ between 20 and 70 years, scheduled the neuromonitoring for spine surgery in department of neurosurgery
Exclusion
- Taking thiazide/ACEi /ARB for hypertension
- Receiving insulin treatment due to diabetes mellitus
- Diagnosed with kidney disease or GFR \< 60
- Diagnosed with liver disease or AST/ALT \> 100
- Receiving furosemide or mannitol before surgery
- DI was diagnosed before surgery or having polyuria
- Taking lithium or antibiotics that are known to cause DI
- Do not understand Korean language
- Vulnerable subjects who are unable to obtain consent forms
Key Trial Info
Start Date :
August 19 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 15 2021
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04058106
Start Date
August 19 2019
End Date
July 15 2021
Last Update
July 20 2021
Active Locations (1)
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1
Myoung Hwa Kim
Seoul, South Korea, 06273