Status:
COMPLETED
Mechanism of Action of Electroconvulsive Therapy
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Unipolar Depression
Bipolar Depression
Eligibility:
All Genders
18-65 years
Brief Summary
This is an observational neuroimaging study assessing the effects of ECT on the brains of patients with unipolar and bipolar depression.
Detailed Description
This project aims to use functional connectivity magnetic resonance imaging (fcMRI) to study patients with unipolar and bipolar depression receiving ECT. Patients will be scanned before and after a fu...
Eligibility Criteria
Inclusion
- Males and Females Between Ages of 18 and 65
- Diagnosis of Major Depressive Disorder without Psychotic Features or Bipolar I/II
- Requiring ECT Treatment as Part of Psychiatric Care
Exclusion
- Comorbid diagnoses of Major Depressive Disorder with Psychotic Features, Schizoaffective Disorder, Schizophrenia or Dementia
- History of Psychosis
- Substance Use Disorder (Abuse or Dependence) with Active Use Within Last 6 Months
- Severe or Unstable Medical Illness
- Medical Contraindication to Anesthesia or ECT (e.g., Recent Myocardial Infarction)
Key Trial Info
Start Date :
June 28 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 31 2024
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT04059952
Start Date
June 28 2019
End Date
May 31 2024
Last Update
June 12 2025
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02129