Status:
COMPLETED
Endovascular Denervation Improves Limb Ischemia in Patients With Peripheral Artery Disease
Lead Sponsor:
Zhongda Hospital
Conditions:
PAD
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Sympathetic overactivity partly promotes the development of peripheral artery disease which mainly leads to ischemia of the lower limbs. Endovascular arterial denervation (ED) is a minimally invasive ...
Detailed Description
Peripheral arterial disease(PAD) show insufficient blood supply of diseased limbs, which causes intermittent claudication of lower limbs, reduced skin temperature, pain, and chronic progressive diseas...
Eligibility Criteria
Inclusion
- eligible subjects aged 18-75 years,
- clinically confirmed PAD in the lower extremities,
- Rutherford category II-VI.
Exclusion
- thrombolytic therapy performed within 30 days,
- patients who had undergone vascular bypass surgery before this study,
- allergy or contraindication of antiplatelet drugs, anticoagulants, thrombolytic drugs and contrast agents,
- patients with obvious bleeding tendency, coagulation dysfunction, hypercoagulability and blood system diseases,
- serious liver and kidney diseases,
- history of hemorrhagic stroke within last month or ischemic stroke or transient ischemic attack within 2 weeks,
- pacemaker implants,
- patients who are pregnant, breast-feeding or planning pregnancy,
- expected survival \< 24 months.
Key Trial Info
Start Date :
August 23 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2021
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT04060797
Start Date
August 23 2019
End Date
September 30 2021
Last Update
May 20 2024
Active Locations (1)
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1
Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China, 210009