Status:
COMPLETED
Neural Mechanisms of Cost and Benefit Integration During Decision-Making, Aim 2: Acute & Lifetime Stress
Lead Sponsor:
NYU Langone Health
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Healthy
Eligibility:
All Genders
18-64 years
Brief Summary
The central aim of this study is to characterize how the costs of acute and lifetime stress affect the neural architecture for decision-making in healthy humans. Investigators will use behavioral choi...
Eligibility Criteria
Inclusion
- English as a native language
- Corrected-to-normal vision
- Individuals on diets to maintain or lose weight, or those not on a diet
- All races, ethnicities, and cultures
Exclusion
- For all fMRI studies we will exclude participants who meet one of the standard CBI MRI exclusion criteria (see attached exclusion questionnaire) prior to participation. This screening questionnaire will be administered prior to scheduling the study, and once again before the scanner session during the second consenting procedure.
- History of and/or medication for neurological or psychiatric disorders
- High blood pressure, heart condition or related medical conditions
- Diabetes, metabolic disorders, history of eating disorders, or food allergies
- Pregnancy
- Handedness (this has been shown be indicative of variations in brain circuitry)
- Since we will measure stress hormones, subjects currently taking corticosteroids or beta-blockers will be ineligible to participate, as these medications have been found to dramatically alter stress hormone levels.
- Furthermore, evidence suggests that fluctuations in bodily hormones (such as that induced through hormonal contraceptives or different stages of menstrual cycle phase) can affect stress hormone levels (Tersman, Collins, \& Eneroth, 1991; Kirschbaum et al, 1999; Andreano, Arjomanid, Cahill, 2008). In order to account for hormonal differences, we will ask female participants if they are taking oral contraceptives. Likewise, we propose to use a simple, non-invasive questionnaire to determine cycle phase, as in McCormick \& Teillon, 2001. We may need to exclude on the basis of whether or not female participants use hormone-based contraceptives, which, for the reason stated above, could be a potential confound.
- In some cases, we will pre-screen subjects to ensure they are on a diet to maintain or lose weight in order to examine how dietary and health goals influence decisions about self-control and rewards.
Key Trial Info
Start Date :
May 1 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2022
Estimated Enrollment :
397 Patients enrolled
Trial Details
Trial ID
NCT04060966
Start Date
May 1 2019
End Date
August 1 2022
Last Update
July 25 2023
Active Locations (1)
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1
NYU Langone Health
New York, New York, United States, 10016