Status:
UNKNOWN
Toripalimab With Preoperative Chemoradiotherapy for LA-EGJ
Lead Sponsor:
Peking University
Conditions:
PD-1
Chemoradiotherapy
Eligibility:
All Genders
18-75 years
Phase:
PHASE1
PHASE2
Brief Summary
This study aims to investigate the safety and efficacy of radiotherapy combined with Toripalimab (PD-1 inhibitor) in the treatment of locally advanced adenocarcinoma of the gastroesophageal junction.
Detailed Description
In this study, patients with locally advanced adenocarcinoma of gastroesophageal junction will be enrolled to explore the safety and efficacy of preoperative radiotherapy and chemotherapy combined wit...
Eligibility Criteria
Inclusion
- 1\) Age 18-75, male and female.
- 2\) ECOG score was 0-1.
- 3\) Diagnosis of adenocarcinoma in the gastroesophageal junction.
- 4\) Initial treatment of locally advanced patients (cT3-4 or N+, and M0).
- 5\) The estimated survival time will be more than 12 months.
- 6\) Adequate organ reserve function.
- 7\) agree to join the group, willing to cooperate with clinical research, and sign the informed consent.
Exclusion
- 1\) Patients have received immunotherapy, such as PD-1 antibody, PD-L1 antibody and CTLA4 antibody.
- 2\) Immunosuppressive drugs were used within 4 weeks before admission.
- 3\) Active infection, acute myocardial infarction in recent 6 months, severe arrhythmia requiring long-term drug intervention, severe stroke, uncontrolled epilepsy or other serious medical complications.
- 4\) In the past five years, there have been other malignant diseases except for cured skin cancer and cervical cancer in situ.
Key Trial Info
Start Date :
August 26 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 25 2023
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT04061928
Start Date
August 26 2019
End Date
August 25 2023
Last Update
August 20 2019
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