Status:
COMPLETED
Memory & Conditioning Under Anesthesia
Lead Sponsor:
Keith M Vogt
Collaborating Sponsors:
National Institute of General Medical Sciences (NIGMS)
Conditions:
Anesthesia
Pain
Eligibility:
All Genders
18-39 years
Phase:
PHASE1
Brief Summary
The purpose of this study is to determine the effects of pain on long-term memory and conditioned physiologic responses in the presence and absence of distinct intravenous anesthetics. Functional magn...
Detailed Description
Purpose: Sedative-hypnotic and analgesic agents (termed "anesthetics") are routinely used during medical procedures to prevent or ease suffering, suppressing the conscious experience of pain and its e...
Eligibility Criteria
Inclusion
- Adults, age 18-39, who are native English speakers with at least a high school education
- have normal hearing and memory
- be of normal body-weight
- be generally healthy (free from significant chronic disease)
- have none of the specific exclusion criteria
- have a valid email address and valid phone number throughout the study
- anticipate ability to participate in all visits required for the phase of the study in which they are enrolled
Exclusion
- Pregnancy
- Body mass index \> 35 (obese) or \< 18 (underweight)
- Use of psychotropic medications, including anti-epileptics, anti-psychotics, anxiolytics, anti-depressants, stimulants, sleep-aids, anti-histamines, or analgesics
- History of adverse reaction to OR abuse of: dexmedetomidine (Precedex), propofol (Diprivan) or the opioids class of medications (fentanyl, morphine, hydromorphone, etc)
- History of clinically significant memory or hearing loss
- History of obstructive sleep apnea
- History of neurologic or psychiatric disease, including benign tremor
- History of significant cardiac disease, including high blood pressure or arrhythmia
- History of significant pulmonary disease
- History of diabetes or neuropathy
- History of chronic pain, or other pain processing disorder
- Have an implanted medical electronic device
- Have indwelling or implanted metal in their body that is not MRI-compatible
- Have claustrophobia
- Have a history of drug abuse
Key Trial Info
Start Date :
July 30 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 22 2024
Estimated Enrollment :
92 Patients enrolled
Trial Details
Trial ID
NCT04062123
Start Date
July 30 2020
End Date
April 22 2024
Last Update
April 18 2025
Active Locations (1)
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1
University of Pittsburgh Medical Center
Pittsburgh, Pennsylvania, United States, 15213