Status:
COMPLETED
Cardiac Magnetic Resonance Assessment for Heart Failure With Preserved Ejection Fraction
Lead Sponsor:
The University of Hong Kong
Conditions:
Heart Failure With Preserved Ejection Fraction
Eligibility:
All Genders
Phase:
NA
Brief Summary
This is a prospective study that aims to define the utility of cardiac magnetic resonance feature tracking (CMR-FT) as a non-invasive quantification tool to assess diastolic functionality in patients ...
Detailed Description
Despite the increasing prevalence and poor prognosis of HFpEF worldwide, it is facing diagnostic challenges due to its non-specific clinical manifestations. Currently, echocardiography serves as the m...
Eligibility Criteria
Inclusion
- Patients presenting with symptoms and signs suggestive of HFpEF
- Patients undergoing coronary catheterisation for stable chest pain with no evidence of diastolic dysfunction, heart failure, infarct, left ventricular ejection fraction \<50% or significant coronary artery disease (ie. \>50% narrowing of one or more coronary arteries)
- Volunteers must be asymptomatic with no cardiac risk factors and no previous cardiac history
Exclusion
- Patients suspected to have HFpEF but echocardiography and/or invasive pressure measurements do not confirm diagnosis of HFpEF.
- Significant underlying ischaemia based on clinical history and non-invasive imaging or catheter coronary angiography if indicated.
- Contraindication to CMR study
- Estimated glomerular filtration rate \<30 ml/min/1.73 m2
- More than moderate valvular disease
- Severe pulmonary disease (ie. FEV1 \<- 50% predicted)
- Cardiomyopathy
- Constrictive pericarditis
Key Trial Info
Start Date :
June 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2021
Estimated Enrollment :
172 Patients enrolled
Trial Details
Trial ID
NCT04063579
Start Date
June 1 2018
End Date
December 31 2021
Last Update
May 10 2023
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The University of Hong Kong
Hong Kong, Hong Kong