Status:
COMPLETED
Preventing Levodopa Induced Dyskinesia in Parkinson's Disease With HMG-CoA Reductase Inhibitors
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
Oregon Health and Science University
Conditions:
Parkinson Disease
Dyskinesia, Drug-Induced
Eligibility:
All Genders
50+ years
Brief Summary
In this study, the investigators will examine the association of statin use and dyskinesia in a convenience sample Parkinson's disease patients in the Veterans Administration Health Care System.
Detailed Description
Long term treatment with levodopa, the gold standard treatment of Parkinson's disease (PD), can lead to the development of abnormal involuntary movements called levodopa induced dyskinesia (LID). The ...
Eligibility Criteria
Inclusion
- Parkinson's Disease
- Age diagnosed with Parkinson's Disease greater than or equal to 50 years
- Treatment with levodopa greater than or equal to 5 years
Exclusion
- Deep Brain stimulation
- Unable to stand for 1 minute intervals, or sensory deficits in the feet
- Significant cognitive impairment as measured by the Montreal Cognitive Assessment score of \< 18
- Subjects with unstable medical or psychiatric conditions (including hallucinations).
- History of unstable medical conditions (i.e. active cardiac disease, recent unwellness, surgery etc.)
- Current use of drugs that may affect parkinsonism or dyskinesia:
- dopamine receptor blocking medications
- depakote
- lithium
- amiodarone
- tetrabenazine
- metoclopramide
- dronabinol
- and illicit drugs such as marijuana (THC)
- cocaine
- methamphetamine
- Statins other than simvastatin or lovastatin, atorvastatin ie. fluvastatin (rationale is that while all other statins are thought to not cross the blood brain barrier well, the central nervous system penetrating nature of others is not perfectly clear and could confound results)
Key Trial Info
Start Date :
August 22 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
March 31 2024
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT04064294
Start Date
August 22 2019
End Date
March 31 2024
Last Update
April 11 2025
Active Locations (3)
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1
VA Portland Health Care System, Portland, OR
Portland, Oregon, United States, 97207-2964
2
Oregon Health & Science University
Portland, Oregon, United States, 97239not
3
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, United States, 98108