Status:
SUSPENDED
Does DHEA IVF Outcomes in Poor Responders?
Lead Sponsor:
Homerton University Hospital NHS Foundation Trust
Conditions:
Infertility, Female
Poor Response to Ovulation Induction
Eligibility:
FEMALE
40-42 years
Phase:
PHASE2
PHASE3
Brief Summary
This study is a RCT to examine whether DHEA is capable of improving results for poor responders to ovarian stimulation during IVF treatment
Detailed Description
Poor responders to ovarian stimulation for IVF may be either predicted or evidenced from previous treatment. The ESHRE criteria for poor responders will be used to select candidates for this trial. A ...
Eligibility Criteria
Inclusion
- Age ≥ 40 years
- Markers for poor ovarian reserve (AMH \<7 pmol/L(\<1.1 ng/ml) and/or AFC\< 7)
- Previous poor response to ovarian stimulation ( ≤3 oocytes with a conventional stimulation protocol)
Exclusion
- Women \> 42 years
- Women with premature ovarian failure / premature menopause (FSH\>40 U/L). Women already taking DHEA.
- Patients with a known allergy to the trial drug or any of the active ingredients in the placebo.
Key Trial Info
Start Date :
October 8 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
400 Patients enrolled
Trial Details
Trial ID
NCT04066478
Start Date
October 8 2017
End Date
December 31 2022
Last Update
June 23 2022
Active Locations (1)
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1
Homerton Fertility Centre
London, United Kingdom, E9 6SR