Status:
COMPLETED
Vitamin D in Systemic Sclerosis Patients With Periodontitis
Lead Sponsor:
University of Messina
Conditions:
Vitamin D Deficiency
Eligibility:
All Genders
20-75 years
Brief Summary
Vitamin D has been considered to possess anti-inflammatory and antimicrobial activity which may be a link for the known interaction of Systemic Sclerosis (SSc) and coronary heart disease (CHD). This s...
Detailed Description
Using a cross-sectional design, a total of 42 patients with SSc, 43 patients with CHD, 41 patients with both SSc and CP, and 42 healthy patients were enrolled in the present study.
Eligibility Criteria
Inclusion
- Presence of at least twenty teeth
- CP with a minimum of 40% of sites with a clinical attachment level (CAL)
- ≥2mm and probing depth (PD) ≥4mm;
- Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- Presence of ≥40% sites with bleeding on probing (BOP)
Exclusion
- Intake of contraceptives
- Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- Status of pregnancy or lactation
- Previous history of excessive drinking
- Allergy to local anaesthetic
- Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
Key Trial Info
Start Date :
November 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
May 30 2019
Estimated Enrollment :
168 Patients enrolled
Trial Details
Trial ID
NCT04066842
Start Date
November 1 2015
End Date
May 30 2019
Last Update
August 26 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Messina
Messina, Italy, 98125