Status:
RECRUITING
Septic Shock-induced Immunosuppression
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Septic Shock
Eligibility:
All Genders
18+ years
Brief Summary
Septic syndromes are a major although largely under-recognized health care problem and represent the first cause of mortality in intensive care units (ICU). While it has long been known that sepsis de...
Eligibility Criteria
Inclusion
- Age over 18 years
- Patient admitted to ICU
- Diagnosis of septic shock within less than 48h at time of screening defined by :
- Presence of a microbiologically diagnosed or suspected infection
- Initiation of a vasopressive treatment to maintain mean arterial blood pressure ≥ 65 mm Hg initiated during the first 48h after ICU admission
- Presence of an hyperlactatemia \> 2 mmol/L (18 mg/dL) during the 24h before or after initiation of vasopressive treatment despite adequate volemic reanimation (30 ml/kg)
- Blood sample at D3/D4 available (lab working days)
- Non opposition to study participation obtained from patient or next of kin
Exclusion
- Pregnant or breastfeeding woman
- Patient with no social security insurance, with restricted liberty or under legal protection
- Language barrier
- Patient taking part in interventional study about medicin that could interfere with biologic results
Key Trial Info
Start Date :
October 21 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 21 2024
Estimated Enrollment :
305 Patients enrolled
Trial Details
Trial ID
NCT04067674
Start Date
October 21 2019
End Date
November 21 2024
Last Update
June 12 2024
Active Locations (1)
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1
Hôpital Edouard Herriot
Lyon, France, 69003