Status:
ACTIVE_NOT_RECRUITING
Mechanisms of Exercise Intolerance in Heart Failure With Preserved Ejection Fraction
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
The University of Texas at Arlington
Conditions:
Heart Failure, Diastolic
Eligibility:
All Genders
60-90 years
Phase:
NA
Brief Summary
The global objective of this study is to determine the mechanisms of exercise intolerance and dyspnea on exertion (DOE) in patients with HFpEF and based on this pathophysiology, test whether specific ...
Detailed Description
This will be a randomized, non-blinded prospective intervention testing the effects of two types of exercise training, whole body and isolated single leg, on HFpEF patients with either central or peri...
Eligibility Criteria
Inclusion
- signs and symptoms of heart failure
- an ejection fraction \> 0.50
- objective evidence of diastolic dysfunction
Exclusion
- age \< 60 years
- BMI \> 50 kg/m2
- PDE5 inhibitor use
- Severe valvular disease
- Severe COPD
- CKD 4 or higher
- Contra-indication to MRI.
Key Trial Info
Start Date :
August 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2025
Estimated Enrollment :
93 Patients enrolled
Trial Details
Trial ID
NCT04068844
Start Date
August 1 2019
End Date
December 31 2025
Last Update
January 1 2025
Active Locations (1)
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1
The Institute for Exercise and Environmental Medicine
Dallas, Texas, United States, 75231