Status:
COMPLETED
ObseRvation After Acute Coronary Syndrome for deveLopment of trEatment Options
Lead Sponsor:
Central State Medical Academy
Conditions:
Acute Coronary Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
The aim of the study is developing an individualized risk model for the unfavorable outcomes of coronary artery disease and complications from ongoing therapy, according to clinical, instrumental, bio...
Detailed Description
The role of genetic factors in the development of coranary heart disease (CHD) exacerbations studied not enough. Most research in this area planned and carried out on a "case-control". Using a similar...
Eligibility Criteria
Inclusion
- Patients with acute coronary syndrome without ST-segment elevation meeting the criteria of a very high, high or intermediate risk, and patients from the low-risk group, if they have episodes of myocardial ischemia in any way Very high risk (1 criterion is sufficient)
- Pulmonary edema, most probably due to ischemia.
- The newly appears or increased noise of mitral regurgitation.
- Rhythm of the gallop, newly developed or intensified wheezing in the lungs.
- Hypotension against ischemia
- Ischemia refractory to treatment
- Persistent ventricular tachycardia or the occurrence of ventricular rhythm disturbances during an attack of ischemia High risk
- (1 criterion is sufficient)
- An anginal attack more than 20 minutes within the next 48 hours before admission
- Transitional elevations ST (duration less than 20 min)
- GRACE score \> 140 points
- Increased cardiospecific markers of necrosis. (you must have at least 2 criteria)
- Age\> 75 years.
- Angina pectoris with transient changes ST\> 0.05 mV.
- Intermediate risk (1 criterion is sufficient)
- Age\> 75 years.
- Angina pectoris with transient changes ST\> 0.05 mV.
- Inversion of the T wave on ECG (≥ 0.2 mV).
- GRACE score 104-139 points
- (it is necessary to have at least 2 criteria)
- Angina of rest (\<20 min), stopped spontaneously or with the help of nitroglycerin (NG).
- Anamnesis of pathology of peripheral or cerebral arteries,
- Postponed myocardial infarction, including painless, history of revascularization (PCI or CABG)
- Diabetes.
- Chronic renal failure (GFR \<50 mL / min)
- Low risk All other patients with suspicion of ACS require a survey to identify episodes of ischemia
- Patients with acute coronary syndrome with ST-segment elevation
- Patients who were hospitalized with symptoms due to acute myocardial infarction (the duration of infarction is no more than 10 days, by the time of hospitalization) and at least one of the following additional criteria identified upon admission to hospital:
- ST elevation: a persistent ST increase of 1 mm in two adjacent leads from the limbs, or an ST increase of 2 mm in two adjacent thoracic leads
- the appearance of a new left bundle branch block
- dynamics of acute myocardial infarction
- Signed informed consent to participate in the study
Exclusion
- Lack of patient consent to participate in the study
- Impossibility of contact with the patient after discharge after index event
Key Trial Info
Start Date :
November 5 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 20 2025
Estimated Enrollment :
1655 Patients enrolled
Trial Details
Trial ID
NCT04068909
Start Date
November 5 2014
End Date
October 20 2025
Last Update
December 18 2025
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