Status:
COMPLETED
The Effect of Inhaled Nitric Oxide on Deadspace in COPD
Lead Sponsor:
Dr. Denis O'Donnell
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
45+ years
Phase:
EARLY_PHASE1
Brief Summary
Chronic obstructive pulmonary disease (COPD) is a progressive disease of the respiratory system that generally develops as a result of smoking. Most people with COPD are classified as having "mild" di...
Detailed Description
This study will recruit 20 current or ex-smokers who meet the criteria for mild chronic obstructive pulmonary disease (COPD), measured by lung function tests. Participation is voluntary and participan...
Eligibility Criteria
Inclusion
- clinically stable as defined by stable hemodynamic status, optimized medical treatment, no changes in medication dosage or frequency of administration with no hospital admission in the preceeding 6 weeks
- current or ex-smokers (\>=20 pack-years)
- male or female \>45 years of age
- mild COPD as defined by Medical Research Council dyspnea scale \>=3 and post-bronchodilator FEV1 \>=80% predicted and FEV1/FVC \<0.7 and \<LLN
- ability to perform all study procedures and provide/sign informed consent
Exclusion
- women of childbearing age who are pregnant or trying to become pregnant
- active cardiopulmonary disease or other comorbidities that could contribute to dyspnea and exercise limitation
- important contraindications to clinical exercise testing, including inability to exercise because of neuromuscular or musculoskeletal disease(s)
- use of daytime oxygen, or exercise-induced O2 desaturation to \<80% on room air
- body mass index (BMI) \<18.5 or =\>35.0 kg/m2
- echocardiographic evidence of pulmonary hypertension
- prior history of pulmonary thromboembolism or systemic vasculopathy
Key Trial Info
Start Date :
September 1 2021
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 30 2023
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT04069052
Start Date
September 1 2021
End Date
May 30 2023
Last Update
April 3 2024
Active Locations (1)
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1
Respiratory Investigation Unit, Kingston General Hospital
Kingston, Ontario, Canada, K7L 2V7