Status:
COMPLETED
The Efficacy of Remote Ischemic Conditioning on Stroke-induced Immunodeficiency
Lead Sponsor:
Capital Medical University
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
to detect the effects of RIC on stroke-induced immunodeficiency and inflammation response in acute ischemic stroke patients
Detailed Description
Remote ischemic conditioning, consisting of several brief cycles of intermittent ischemia-reperfusion of the arm or leg, may potentially confer systemic protection against prolonged ischemia in a dist...
Eligibility Criteria
Inclusion
- Age≥18 years old;
- Confirmed diagnosis of acute ischemic stroke(AIS) with onset of symptoms within 48h at recruitment;
- NIHSS score: ≤15;
- Prestroke modified Rankin Scale(mRS) ≤2;
- subject or his or her legally authorized representative was able to provide informed consent.
Exclusion
- uncontrolled hypertension (defined as systolic blood pressure ≥200 mmHg);
- participation in another device or drug trial simultaneously;
- any vascular, soft tissue, or orthopedic injury (eg, superficial wounds and fractures of the arm) that contraindicated unilateral arm ischemic preconditioning;
- peripheral vascular disease (especially subclavian arterial and upper limb artery stenosis or occlusion);
- Women who have a positive pregnancy test;
- History of malignancies;
- Using remote ischemic conditioning within the preceding 1 week;
- known infection at admission;
- a history of infection or the use of antibiotics, immunosuppressants, or steroids within the preceding 3 months.
- Other conditions are not suitable for this trial (evaluated by researchers)
Key Trial Info
Start Date :
September 7 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2020
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT04069546
Start Date
September 7 2019
End Date
February 1 2020
Last Update
December 28 2020
Active Locations (1)
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1
Xuanwu Hospital, Capital Medical University
Beijing, XI Cheng District,, China, 100053