Status:
UNKNOWN
Skin Biopsy in the Diagnosis of Small Fiber Neuropathy in Chinese Patients With Diabetes
Lead Sponsor:
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Conditions:
Small Fiber Neuropathy
Diabetic Neuropathies
Eligibility:
All Genders
18-75 years
Brief Summary
To detect small fiber neuropathy in patients with possible or established diabetic peripheral neuropathy (DPN) by skin biopsy and explore clinical characteristics and pathological features in Chinese ...
Detailed Description
Small fiber neuropathy (SFN) is a subtype of diabetic neuropathy, patients with SFN often manifest as paresthesia of warmth, cold, pinprick and so on, especially affect ed length-dependent area. Skin ...
Eligibility Criteria
Inclusion
- Age ≧ 18 and ≦75 years old
- A history of diabetes
- Symptoms of small fiber neuropathy such as pain, paresthesia, acanthesthesia after diagnosed with diabetes
Exclusion
- Acute skin infection or injury
- Coagulation disorders
- History of malignant tumor
- Usage of neurotoxic drugs
- Alcohol abuse
- Vascular diseases, e.g. LEASO and stroke
- Infectious diseases, e.g. hepatitis B, HIV, and syphilis
- Metabolic disorders, e.g. hypothyroidism, hyperlipidemia, and amyloid lesions
- Connective tissue diseases
- Nutritional disorders, e.g.vitamin B6 deficiency, and vitamin B12 deficiency
- Other causes of peripheral neuropathy, e.g. lumbar disc herniation, Guillain-Barre Syndrome, and polyradiculopathy
Key Trial Info
Start Date :
December 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 1 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04071535
Start Date
December 1 2015
End Date
July 1 2021
Last Update
August 28 2019
Active Locations (1)
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1
at Division of Endocrinology, the Affiliated Drum Tower Hospital of Nanjing University
Nanjing, Jiangsu, China, 210008