Status:
ACTIVE_NOT_RECRUITING
PET Imaging of Giant Cell and Takayasu Arteritis
Lead Sponsor:
University of Cambridge
Collaborating Sponsors:
Cambridge University Hospitals NHS Foundation Trust
Wellcome Trust
Conditions:
Giant Cell Arteritis
Takayasu Arteritis
Eligibility:
All Genders
18-99 years
Brief Summary
While 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging is often included in the diagnostic work-up of patients with large-vessel vasculitis (LVV), 18F-FDG lacks specificity for ...
Detailed Description
Up-regulation of SST2 in activated macrophages represents a novel imaging target for measuring vascular inflammation, which has been previously examined in atherosclerosis using 68Ga-DOTATATE. To test...
Eligibility Criteria
Inclusion
- Male or female participants \>18 years old
- Able to give written, informed consent and to lie flat
- Either:
- New clinical diagnosis or acute flare of LVV (Giant-cell arteritis or Takayasu's arteritis) within \~1 week of treatment initiation, and
- Clinical indication for 18F-FDG PET-CT scan determined by the referring physician, or
- Undergoing surgery for LVV, or
- Diagnosis of LVV in remission
Exclusion
- Women of child bearing potential not using adequate contraception
- Contra-indication to MRI scanning
- Contrast allergy or contrast-nephropathy
- Chronic kidney disease (eGFR \<30 mL/min/1.73 m2)
- Any medical condition, in the opinion of the investigator, that prevents the participant from lying flat during scanning, or from participating in the study
- History of recent malignancy deemed relevant to the study by the investigator
Key Trial Info
Start Date :
June 25 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2025
Estimated Enrollment :
27 Patients enrolled
Trial Details
Trial ID
NCT04071691
Start Date
June 25 2019
End Date
April 1 2025
Last Update
July 22 2024
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Cambridge
Cambridge, Cambridgeshire, United Kingdom, CB2 2QQ
2
Imperial College Healthcare NHS Trust
London, United Kingdom, W12 0NS