Status:
COMPLETED
Clopidogrel Preventive Effect Based on CYP2C19 Genotype in Ischemic Stroke
Lead Sponsor:
Gangnam Severance Hospital
Collaborating Sponsors:
SAMJIN PHARM
Conditions:
Acute Ischemic Stroke
Eligibility:
All Genders
19+ years
Brief Summary
The hypothesis of this study is that "the poor metabolizer or intermediate metabolizer of the cytochrome P450 2C19 genotype in patients with acute ischemic stroke is associated with increased risk of ...
Detailed Description
Clopidogrel, one of the antiplatelet agents used for secondary prevention in patients with ischemic stroke and coronary artery disease, has been shown to have a superior antiplatelet effect compared t...
Eligibility Criteria
Inclusion
- Ischemic stroke confirmed by brain CT or MRI
- Patient who received clopidogrel within 72 hours after onset of ischemic stroke
- Adults over 19 years
- Patients who agreed to participate in this study within 7 days after ischemic stroke
- Patients who underwent Cytochrome P450 2C19 genotype test.
Exclusion
- Patients who currently take anticoagulation or is expected to take anticoagulation with 6 months from the screening date
- Patients who need other antiplatelet drugs except aspirin and clopidogrel
- Patients who were taking clopidogrel prior to ischemic stroke
- Patients scheduled for coronary artery stenting, coronary artery bypass surgery, carotid endarterectomy, carotid and cerebral artery stenting
- Patients with severe comorbidities or active cancer with an estimated life expectancy of less than two years
- Patients who participated in other drug clinical trials within the past 30 days
- Patients with high risk source of potential cardiac source of embolism in TOAST classification
- Patients who are expected to unable to participate or continue the study
Key Trial Info
Start Date :
September 20 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
July 7 2023
Estimated Enrollment :
2927 Patients enrolled
Trial Details
Trial ID
NCT04072705
Start Date
September 20 2019
End Date
July 7 2023
Last Update
September 25 2023
Active Locations (37)
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1
Yongin Severance Hospital
Yongin-si, Gyeonggi-do, South Korea, 16995
2
Department of Neurology Korea University Ansan Hospital
Ansan, South Korea, 15355
3
Department of Neurology Hallym University Sacred Heart Hospital
Anyang, South Korea, 14068
4
Department of Neurology Inje University Busan Paik Hospital
Busan, South Korea, 47392