Status:
COMPLETED
A Multiple Centre, Cohort Study of New CRRT Membranes oXiris for Patients With Septic Shock
Lead Sponsor:
Southeast University, China
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Acute Kidney Injury Due to Sepsis (Disorder)
Eligibility:
All Genders
18+ years
Brief Summary
The objectives of this study are to determine whether Continuous Renal Replacement Therapy (CRRT) with oXiris in patients with septic shock would improve clinical outcomes such as the sepsis-related o...
Detailed Description
Sepsis is the leading cause of death in ICU, resulting in multi-organ failure in critically ill patients. Patients with septic shock combined sepsis-associated Acute kidney injury (AKI)have even poore...
Eligibility Criteria
Inclusion
- \>18 Years
- Treated by CRRT using oXiris or conventional membrane
- SOFA cardiovascular Score ≥ 3
- Septic shock due to abdominal or pneumonia( Gram-negative bacterial infection or suspected GNB infection)
- Written informed consent
Exclusion
- Chronic Kidney Disease
- Renal replacement therapy (RRT) in the last 30 days
- Pregnancy
- Immunosuppressive treatment or steroids (prednisone \> 0.5 mg/kg/day or equivalent).
- Autoimmune disorder.
- Transplant receptor.
- Inclusion in other ongoing studies within the last 30 days.
- Coexisting illness with a high probability of death
Key Trial Info
Start Date :
September 21 2019
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 31 2021
Estimated Enrollment :
590 Patients enrolled
Trial Details
Trial ID
NCT04073771
Start Date
September 21 2019
End Date
October 31 2021
Last Update
December 2 2022
Active Locations (2)
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1
Zhongda Hospital, Southeast University
Nanjing, Jiangsu, China, 210009
2
Department of Nephrology, Sichuan University West ChinaHospital
Chengdu, Sichuan, China