Status:
ACTIVE_NOT_RECRUITING
Residual Inflammation and Plaque Progression Long-term Evaluation
Lead Sponsor:
University of Cambridge
Collaborating Sponsors:
Cambridge University Hospitals NHS Foundation Trust
Wellcome Trust
Conditions:
Atherosclerosis
Myocardial Infarction
Eligibility:
All Genders
18-99 years
Brief Summary
Inflammation drives atherosclerotic plaque rupture triggering most acute coronary syndromes. Despite advances in diagnosis and management of atherosclerosis, patients with myocardial infarction (MI) r...
Detailed Description
While vascular inflammation can be detected using 18F-FDG PET, this method lacks inflammatory cell specificity and is unreliable for coronary imaging because of high background signals from the myocar...
Eligibility Criteria
Inclusion
- Male or female participants \>18 years old
- Able to give written, informed consent and to lie flat
- First-presentation of myocardial infarction within \~2 weeks
- At least mild non-culprit coronary artery disease on angiography, managed medically
Exclusion
- Women of child bearing potential not using adequate contraception
- Contrast allergy or contrast-nephropathy
- Uncontrolled atrial fibrillation
- Chronic kidney disease (eGFR \<30 mL/min/1.73 m2)
- Any medical condition, in the opinion of the investigator, that prevents the participant from lying flat during scanning, or from participating in the study
- Uncontrolled chronic inflammatory disorder
- History of recent malignancy deemed relevant to the study by the investigator
- Current use of systemic corticosteroids
- Previous coronary artery bypass grafting surgery (CABG) or percutaneous coronary intervention (PCI) before the index event
- Contraindication to coronary angiography
- Requires CABG or staged non-culprit artery PCI
Key Trial Info
Start Date :
October 1 2020
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
April 1 2025
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04073810
Start Date
October 1 2020
End Date
April 1 2025
Last Update
July 19 2024
Active Locations (1)
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1
University of Cambridge
Cambridge, United Kingdom