Status:
UNKNOWN
Exploration of Brain Changes Due to a Targeted Ballet Program in Multiple Sclerosis
Lead Sponsor:
University of Illinois at Urbana-Champaign
Conditions:
Multiple Sclerosis, Relapsing-Remitting
Eligibility:
All Genders
18-64 years
Phase:
NA
Brief Summary
Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) affecting roughly 900,000 people in the United States that frequently results in impaired mobility. The majority of...
Detailed Description
Multiple sclerosis (MS) is an autoimmune-mediated disease with brain demyelination and axonal loss that result in impaired mobility, which affects an estimated 75% of people with MS and is reported as...
Eligibility Criteria
Inclusion
- Age between 18-64
- Informed consent obtained
- Confirmation of relapsing remitting MS (RRMS) diagnosis by the participant's neurologist
- Presence of ataxia determined by the International Cooperative Ataxia Rating Scale (ICARS) recommended by the NIH and the Ataxia Neuropharmacology Committee of the World Federation of Neurology with a score greater or equal to 7
- Expanded Disability Status Scale (EDSS) scores of 1.0-6.5 based on an examination by a Neurostatus certified examiner for indicating walking impairment
- Relapse free in the previous 30 days
- Approval for exercise training.
Exclusion
- Presence of severe cognitive impairment based on an oral Symbol Digit Modalities Test (SDMT) score of less than 23, or the Montreal Cognitive Assessment (MoCA) Test less than 22
- Inability to understand experimental instructions presented in English
- Pregnancy
- Education level less than 8th grade - due to concerns about understanding the study and consent form
- Change in use of disease modifying therapy in the previous 6 months,
- Initiation of Ampyra or other medications that influence walking and mobility within the previous 30 days,
- History of brain injury or central nervous system disease other than multiple sclerosis - this will be determined from gross anatomical abnormalities in the images or from medical history on Biomedical Imaging Center (BIC) screening form,
- Presence of orthopedic conditions,
- The presence of any skin conditions preventing the safe usage of motion tracking marker adhesives
- The presence of conditions which would contra-indicate MRI: prior surgeries and/or implant of pacemakers, pacemaker wires, artificial heart valve, brain aneurysm surgery, middle ear implant, non-removable hearing aid or jewelry, braces or extensive dental work, cataract surgery or lens implant, implanted mechanical or electrical device, artificial limb or joint; foreign metallic objects in the body such as bullets, BB's, shrapnel, or metalwork fragments; pregnancy, claustrophobia, uncontrollable shaking, or inability to lie still for 2 hours.
Key Trial Info
Start Date :
August 29 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 15 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04073940
Start Date
August 29 2019
End Date
January 15 2021
Last Update
January 3 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University of Illinois at Urbana-Champaign
Champaign, Illinois, United States, 61820