Status:
COMPLETED
Optimal Detection of Atrial Fibrillation in TIA
Lead Sponsor:
Alfried Krupp Krankenhaus
Collaborating Sponsors:
Medtronic Bakken Research
Coordinating Centre for Clinical Trials Heidelberg
Conditions:
Atrial Fibrillation
Transient Ischemic Attack
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
Transient ischemic attack (TIA) is a common neurologic emergency. Although the detection of atrial fibrillation (AF) has identical consequences for preventive therapy in patients with ischemic stroke ...
Detailed Description
Transient ischemic attacks (TIA) are a common neurologic emergency. Clinical management guidelines recommend oral anticoagulation for TIA patients suffering from atrial fibrillation (AF). Therefore, a...
Eligibility Criteria
Inclusion
- Eligibility Criteria:
- Study Population Patients with a recent TIA will be enrolled during a period of approximately 24 months at participating European stroke centres. TIA patients may be enrolled after initial management as inpatients or outpatients. Consecutive screening and enrolment will be strongly encouraged and a screening log will be implemented at each site.
- Inclusion Criteria
- Written informed consent by patient.
- Age ≥ 50 years.
- TIA diagnosed by a stroke physician defined as rapidly developing clinical signs of focal or global disturbances of cerebral function, lasting less than 24 hours with no apparent non-vascular cause
- 12-channel ECG available before enrolment
- Brain imaging available before enrolment (CCT or cranial MRI)
- Vascular imaging of cervical vessels performed
- Enrolment within 28 days after TIA episode. Exclusion Criteria
- Previously documented history of AF
- Ischemic stroke within the last 6 months before enrolment
- Pre-screening monitoring for cardiac arrhythmias lasting ≥72 hours
- AF lasting \> 30 s on a 12 channel ECG or other ECG recording technique prior to enrolment
- Life expectancy less than 1 year.
- Significant stenosis \> 50% in intracranial or extracranial vessels which, in the opinion of the investigator, is the likely cause of the patients TIA.
- Severely disabled patients (i.e. modified Rankin Score \>3)
- Lack of therapeutic consequence in case of diagnosis of AF (e.g. other indication for long term anticoagulation
- Pacemaker or Implanted Cardiac Defibrillator
Exclusion
Key Trial Info
Start Date :
March 12 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 31 2025
Estimated Enrollment :
515 Patients enrolled
Trial Details
Trial ID
NCT04075500
Start Date
March 12 2019
End Date
August 31 2025
Last Update
November 19 2025
Active Locations (27)
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1
Universitätsklinikum Aachen, Neurologie
Aachen, Germany, 52074
2
Rhön Klinikum Campus Bad Neustadt
Bad Neustadt an der Saale, Germany, 97616
3
Vivantes Klinikum Neukölln
Berlin, Germany, 12351
4
Carl-Thiem-Klinikum Cottbus; Klinik für Neurologie
Cottbus, Germany, 03048