Status:
UNKNOWN
Neuroinflammation During ICU-associated Delirium in Critically Ill Patients and Its Association With Structural and Functional Brain Alterations: a Nested Case-control Study
Lead Sponsor:
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Collaborating Sponsors:
University of Pisa
University of Turin, Italy
Conditions:
Delirium
Critical Illness
Eligibility:
All Genders
18+ years
Brief Summary
With the present study, the authors aim to improve the knowledge of the pathophysiology of ICU-related delirium. In particular, the authors would like to clarify the possible correlation between neuro...
Detailed Description
Pathophysiology of delirium is poorly understood; neuroinflammation and brain network disruption are claimed as possible causes of delirium. The authors want to clarify the role of the alterations of...
Eligibility Criteria
Inclusion
- Age\>18
- All patients admitted that would be expected to stay in ICU for at least 3 days
Exclusion
- Acute neurological condition
- Chronic neurological condition (i.e., seizures, stroke, muscular illness).
- Hematological malignancy or immunological disease.
- Blood transfusion in the last 2 weeks
- Ongoing sedation
- Any condition which contraindicates MRI execution (presence of non-compatible devices or hemodynamic or respiratory instability).
Key Trial Info
Start Date :
March 25 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 25 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT04078503
Start Date
March 25 2019
End Date
June 25 2021
Last Update
September 6 2019
Active Locations (1)
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1
Spedali Civili di Brescia
Brescia, Italy, 25123