Status:
RECRUITING
Transurethral Modified En Bloc Resection For Large Bladder Tumours.
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Bladder Cancer
Bladder Neoplasm
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Modified en bloc resection is a hybrid technique involving piecemeal resection of the exophytic part of the bladder tumour, followed by en bloc resection of the tumour base. In this study, we shall in...
Detailed Description
The biggest limiting factor of en bloc resection is the size of the bladder tumour. Resection of the bladder tumour is technically feasible, but the retrieval of specimen in one piece is restricted by...
Eligibility Criteria
Inclusion
- Age 18 to 80 years old with informed consent
- Bladder tumours with maximal dimension of ≥ 3cm
Exclusion
- Bladder tumour detected during intravesical Bacillus Calmette-Guerin therapy (These patients warrant more aggressive treatment, i.e. radical cystectomy)
- Estimated glomerular filtration rate of \<60mL/min.
- Presence of clinically significant cardiovascular disease (History of acute myocardial infarction, presence of uncontrolled angina within 3 months before screening, New York Heart Association Class III or IV congestive heart failure, presence of ventricular arrhythmias, or presence of second-degree or third-degree heart block)
- Presence of GOLD Stage III or IV chronic obstructive pulmonary disease
- History of bleeding disorder or use of anti-coagulant
- Presence of other active malignancy
- ECOG performance status ≥ 2 (Ambulatory and capable of all self care but unable to carry our any work activities. Confined to bed or chair less than 50% of waking hours)
- Pregnancy
- Presence of metallic foreign body or implant which is not MRI compatible
- Known history of claustrophobia
Key Trial Info
Start Date :
September 7 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 30 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04081246
Start Date
September 7 2020
End Date
September 30 2024
Last Update
January 23 2024
Active Locations (1)
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1
Prince of Wales Hospital
Hong Kong, Hong Kong