Status:
COMPLETED
Effect of G6PD Deficiency on Red Blood Cell Storage
Lead Sponsor:
Columbia University
Collaborating Sponsors:
New York Blood Center
Conditions:
G6PD Deficiency
Eligibility:
MALE
18-70 years
Brief Summary
The proposed study will determine whether G6PD-deficient RBCs store differently than normal RBCs under standard blood banking conditions. The investigators plan to screen a large number of healthy mal...
Detailed Description
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency, affecting approximately 400 million people world-wide. It manifests as red blood cell (RBC) destruction in res...
Eligibility Criteria
Inclusion
- Male
- Weight greater than 110 pounds
- Hemoglobin greater than 11.5 g/dL
- African (e.g., Afro-American, Afro-Caribbean, Sub-Saharan), Asian, Hispanic, Middle Eastern, or Mediterranean (e.g., Italian, Greek) based on mother's ancestry
- English speaking
Exclusion
- Presence of hemoglobin variant
- Ineligible for donation based on the New York Blood Center donor autologous questionnaire
- Systolic blood pressure \>180 or \<90 mm Hg, diastolic blood pressure \>100 or \<50 mm Hg
- Heart rate \<50 or \>100
- Temperature \>99.5°F prior to donation
- Temperature \>100.4°F or subjective feeling of illness prior to transfusion (this criterion is to avoid concurrent illness affecting post-transfusion measurements)
- Positive results on standard blood donor infectious disease testing
Key Trial Info
Start Date :
November 1 2012
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2017
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT04081272
Start Date
November 1 2012
End Date
October 1 2017
Last Update
September 17 2019
Active Locations (2)
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1
Columbia University Irving Medical Center
New York, New York, United States, 10032
2
New York Blood Center
New York, New York, United States, 10065