Status:
WITHDRAWN
Targeting the Optimal Mean Arterial Pressure in Hypoxic Ischemic Brain Injury After Cardiac Arrest
Lead Sponsor:
University of British Columbia
Conditions:
Cardiac Arrest
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Hypoxic ischemic brain injury (HIBI) is the ensuing brain injury after cardiac arrest and is the primary cause of adverse outcome. HIBI is caused by low oxygen delivery to the brain. The patient's blo...
Eligibility Criteria
Inclusion
- We will include any patient 19 years or older who are admitted to the ICU following cardiac arrest with a post-resuscitation Glasgow Coma Scale of 8 or less.
- Existing arterial line in situ as part of their clinical care.
- Enrolled within 72 hours of their cardiac arrest
- Patients must have had more than 20 consecutive minutes of spontaneous circulation following resuscitation
- Duration of cardiac arrest greater than 10 minutes prior to return of spontaneous circulation. This is to ensure that we will not be placing intra-parenchymal bolts in patients who are likely to have a favourable neurological outcome regardless of monitoring.
Exclusion
- Coagulopathy (INR \> 1.5, PTT \> 40, Platelets \< 100)
- Cardiac catheterization procedure is anticipated within the next 7 days.
- Current or anticipated use of anticoagulant or antiplatelet medication. Importantly, subcutaneous heparin or dalteparin for deep venous thrombosis prophylaxis may be used provided it is not administered 12 hours prior to insertion or removal of the bolt. This practice is currently utilized in our TBI population.
- Undergoing therapeutic hypothermia with a target temperature under 35oC.
- Known or prior history of severe TBI, intracranial hemorrhage or stroke that would interfere with cerebral oximetry (i.e. significant prior damage to the frontal lobes).
- No current commitment to ongoing support by the medical team
- Acute ST elevation myocardial infarction
- \-
Key Trial Info
Start Date :
October 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2020
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT04081506
Start Date
October 1 2019
End Date
October 1 2020
Last Update
November 4 2020
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