Status:
RECRUITING
68-Ga DOTATATE PET/MRI in the Diagnosis and Management of Somatostatin Receptor Positive CNS Tumors.
Lead Sponsor:
Weill Medical College of Cornell University
Collaborating Sponsors:
Novartis Pharmaceuticals
Conditions:
CNS Tumors
Meningioma
Eligibility:
All Genders
18-100 years
Phase:
PHASE4
Brief Summary
The study population consists of patients who undergo resection for somatostatin receptor-positive (SSTR-positive) CNS tumors, focusing on meningioma, and including esthesioneuroblastoma, hemangioblas...
Detailed Description
Prior to the onset of this study, the utility of Ga-68-DOTATATE PET/MRI in meningioma had not been explored. The investigator's pilot study serving as the basis for the proposed protocol resulted in t...
Eligibility Criteria
Inclusion
- ≥ 18 years of age
- Diagnosis of meningioma based on pathology reports and suspected recurrence or residual disease based on standard-of-care MRI
- Additionally, patients with other somatostatin receptor 2 positive brain tumors, including esthesioneuroblastoma, hemangioblastoma, medulloblastoma, paraganglioma, pituitary adenoma, and SSTR-positive systemic cancers metastatic to the brain will be considered for the purposes of obtaining feasibility data
- As the investigator's institution, PET/MRI scanner utilizes a 3 Tesla (T) magnet, patients who may be ineligible to undergo 3T MRI but may undergo 1.5 Tesla (T) MRI, will undergo a 1.5T MRI as per clinical standard-of-care and a Ga68-DOTATATE PET/CT with the PET portion to be fused with the 1.5T MRI utilizing fusion software.
Exclusion
- Contraindications to gadolinium-based contrast agent
- History of allergic reaction to Gallium-68-DOTATATE
- Pregnancy
Key Trial Info
Start Date :
September 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2038
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT04081701
Start Date
September 4 2019
End Date
December 31 2038
Last Update
November 21 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Weill Cornell Medicine
New York, New York, United States, 10065