Status:
UNKNOWN
Carbon Ion Radiotherapy for Locally Advanced Pancreatic Cancer
Lead Sponsor:
Shanghai Proton and Heavy Ion Center
Conditions:
Pancreatic Carcinoma
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
The aim of this study is to evaluate the toxicity and tolerance of carbon ion radiotherapy for locally advanced pancreatic carcinoma (LAPC)
Detailed Description
The carbon dose of 60-67.5GyE in 15 fractions was delivered to clinical target volume (CTV). The dose limiting toxicity (DLT) was defined as CTCAE grade 3 or higher of non-hematological toxicity (G3)....
Eligibility Criteria
Inclusion
- The histologically or cytologically confirmed, or the clinically diagnosed by clinical diagnosis criterion proposed by Pancreatic Cancer Committee of Chinese Anti-Cancer Association, which was based on evidences of (1). Typical symptoms of abdominal and/or back pain; (2). CA19-9 increased over the normal up limit; (3). A pancreatic mass shown on CT or MRI; and (4). SUV of PET-CT in mass increased compared to that in normal pancreas;
- Unresectable LAPC defined by the criteria of (NCCN) guidelines (Version 1. 2013), or refusal to surgery;
- Gastrointestinal tract (GI) not invaded;
- ECOG Performance Status 0-1 within 30 days prior to registration;
- Age of ≥ 18 years old;
- Enough hematological function (white blood cell count ≥ 3.0×109/L; platelets ≥50×109/L; hemoglobin ≥ 90 g/L);
- Enough liver and kidney functions (creatinine \<110gmol/L; urea nitrogen \<7.1mmol/L; bilirubin \< 1.5 x ULN, ALT and AST ≤ 2.5 x ULN);
- No evidence of distant metastases, based upon PET, CT, or MRI images of the chest, abdomen and pelvis within 30 days prior to registration;
- Informed consent form obtained.
Exclusion
- No pathological evidence of malignant tumor;
- ECOG\>=2；
- Liver, kidney and bone marrow function are poor and not adequate for treatment;
- Side effect of previous treatment is not covered yet, eg. The interval between TACE and other anti-tumor therapy is less than one month;
- Prior radiation therapy to the abdomen or radioactive particle implantation;
- cardiac pacemaker or other metal implantation whose function may be disturbed by high energy beam or which affect the dose in target volume;
- Dose constrain of normal liver, digested system and other OAR could not reach the expecting safe dose constrain;
- The patient could not get benefit from proton or heavy ion radiotherapy in physician's opinion;
- Comitant diseases or affecters which could affect the proton or heavy ion radiotherapy;
- Pregnancy（blood or urine β-HCG certified）or lactation;
- Drug or alcohol abused;
- HIV positive, including received anti-retrovirus treatment; chronic hepatitis B virus replication stage; hepatitis C active stage; syphilis active stage;
- HBV positive, hepatitis B virus replication stage, need to be treated with anti-virus treatment, but could not receive anti-virus treatment because of comitant disease;
- Psychiatric history, possibly affecting the completion of treatment;
- patients with serious complications that might affect radiotherapy， including 1）unstable angina pectoris requiring hospitalization in the last 6 months，congestive heart failure，myocardial infarction； 2）acute bacterial or systemic fungal infections； 3）exacerbation of chronic obstructive pulmonary disease ( COPD) or other respiratory system disease requiring hospitalization 4）hepatic function insufficiency or renal function insufficiency 5） immunosuppressed patients
- patients with connective tissue disease such as active scleroderma or lupus and so on, which is contraindication for radiotherapy
- patients can't understand treatment goal or unwilling/unable to sign up inform consent form；
- no civil capability or limited civil capacity.
Key Trial Info
Start Date :
April 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
49 Patients enrolled
Trial Details
Trial ID
NCT04082455
Start Date
April 1 2018
End Date
June 1 2024
Last Update
December 1 2023
Active Locations (1)
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1
Shanghai Proton and Heavy Ion Center
Shanghai, Shanghai Municipality, China, 201315