Status:
ACTIVE_NOT_RECRUITING
National Unified Renal Translation Research Enterprise - Chronic Kidney Disease
Lead Sponsor:
University of Nottingham
Collaborating Sponsors:
Kidney Cancer UK
UK Renal Registry
Conditions:
Chronic Kidney Diseases
Eligibility:
All Genders
18+ years
Brief Summary
Chronic Kidney Disease (CKD) affects around 10% of the adult population and is associated with an increased risk of heart attack, stroke and end stage kidney disease (ESKD). This study aims to better ...
Detailed Description
3,000 participants will be recruited from nephrology clinics at multiple participating centres (planned to start with 11). 100 control participants (without CKD) will be recruited from among hospital ...
Eligibility Criteria
Inclusion
- Participants with CKD
- Age Over 18 years of age
- Estimated GFR 59-15ml/min/1.73m² or eGFR \>60ml/min/1.73m² and urine albumin to creatinine ratio \>30mg/mmol
- Seen at least once in a Nephrology Clinic
- Willing to participate in two study visits
- Able to give informed consent and participate in study procedures
Exclusion
- Recipient of a solid organ transplant
- Expected survival less than 1 year (in the opinion of local investigators)
- Acute kidney injury within 3 months of recruitment
- Major Acute Cardiovascular Event (MACE) within 3 months of recruitment
- Participants without CKD - controls Inclusion criteria
- Age over 18 years of age
- Willing to participate in one study visit
- Able to give informed consent and participate in study procedures
- No evidence of CKD
- No other major illnesses except for hypertension and type 2 diabetes mellitus (50 participants will have diabetes but no CKD)
- Exclusion criteria
- Estimated GFR\<60ml/min/1.73m2 in previous 12 months or last available result
- Urine albumin to creatinine ratio \>3mg/mmol in previous 12 months or last available result
- Previous unilateral nephrectomy or partial nephrectomy
- Recipient of a solid organ transplant
- Expected survival less than 1 year (in the opinion of local investigators)
Key Trial Info
Start Date :
July 27 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 31 2032
Estimated Enrollment :
3004 Patients enrolled
Trial Details
Trial ID
NCT04084145
Start Date
July 27 2016
End Date
December 31 2032
Last Update
April 3 2025
Active Locations (2)
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1
Royal Derby Hospital
Derby, Derbyshire, United Kingdom, DE22 £NE
2
Salford Royal Hospital
Salford, United Kingdom, M6 8HD