Status:
COMPLETED
Impact of Cardiopulmonary Bypass Flow on Renal Oxygenation, Blood Flow and Tubular Injury
Lead Sponsor:
Sahlgrenska University Hospital
Conditions:
Extracorporeal Circulation; Complications
Renal Failure
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
During open cardiac surgery, cardiopulmonary bypass (CPB) is used to temporarily replace the function of the heart and lungs. Renal ischemia resulting in acute kidney injury is common after cardiac su...
Eligibility Criteria
Inclusion
- Written, signed informed consent
- Male and female subjects ≥18 years
- Left ventricular ejection fraction ≥30 %
- Estimated GFR ≥30 ml/min using the CKD-EPI equation (Levey 2009)
- Scheduled open cardiac surgery with CPB
- Planned normothermia during CPB
- Expected CPB time \> 60 minutes
Exclusion
- Emergency surgery
- Cardiac transplantation
- Advanced grown-up congenital heart disease corrections
- Previous cerebral infarction, verified with computed tomography or magnetic resonance imaging
- Body mass index \> 32 kg/m2
- Use of hypothermia \< 32 °C during CPB
- Inability of the patient to give based opinion
- In the investigator´s opinion, the patient has a condition that could be adversely affected by study participation
Key Trial Info
Start Date :
September 27 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT04084301
Start Date
September 27 2019
End Date
November 1 2023
Last Update
November 22 2023
Active Locations (1)
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1
Lukas Lannemyr
Gothenburg, Västra Götaland County, Sweden, 416 53