Status:
COMPLETED
Investigating the Effects of Daily Consumption of Blueberry (Poly)Phenols on Vascular Function and Cognitive Performance
Lead Sponsor:
King's College London
Collaborating Sponsors:
University of Reading
Conditions:
Healthy Aging
Healthy
Eligibility:
All Genders
65-80 years
Phase:
NA
Brief Summary
Foods rich in certain (poly)phenols, particularly flavonoids, such as berries and cocoa, have been shown to improve measures of vascular function as well as cognitive performance in human intervention...
Detailed Description
To date no study has investigated whether daily blueberry consumption can induce an increase in cerebral blood flow, with subsequent improvements in vascular and cognitive function. In this study, the...
Eligibility Criteria
Inclusion
- Participants will include 60 healthy male and female volunteers, aged 65-80.
- Volunteers will be able to understand the nature of the study and able to give signed written informed consent.
- Subjects willing to maintain their normal eating/drinking habits and exercise habits to avoid changes in body weight over the duration of the study.
Exclusion
- Manifest cardiovascular diseases including coronary artery disease, cerebrovascular disease and peripheral artery disease.
- Hypertensive, as defined as SBP superior or equal to 140 mmHg or DBP superior or equal to 90 mmHg.
- Obese participants, defined as BMI superior or equal to 30.
- Diabetes mellitus and metabolic syndrome.
- Acute inflammation, terminal renal failure or malignancies.
- Allergies to berries or another significant food allergy.
- Subjects under medication or on vitamin/dietary supplements (within 2 weeks of baseline).
- Subjects who have lost more than 10% of their weight in the past 6 months or are currently on a diet.
- Subjects who reported participant in another study within one month before the study starts.
- Subjects who smoke cigarettes irregularly.
- MCI or dyslexic or unable to complete the cognitive function tasks for any reason such as visual impairments.
- Subjects who require chronic antimicrobial or antiviral treatment.
- Subjects with unstable psychological condition.
- Subjects with history of cancer, myocardial infarction, cerebrovascular incident.
- Any reason or condition that in the judgment of the clinical investigator(s) may put the subject at unacceptable risk or that may preclude the subject from understanding or complying with the study's requirements.
Key Trial Info
Start Date :
September 4 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 17 2020
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT04084457
Start Date
September 4 2019
End Date
April 17 2020
Last Update
July 12 2021
Active Locations (1)
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1
Franklin-Wilkins Building, King's College London
London, United Kingdom, SE1 9NH