Status:
COMPLETED
Effect of a Carbohydrate-rich Diet in Healthy Subjects
Lead Sponsor:
Université de Sherbrooke
Collaborating Sponsors:
Hospices Civils de Lyon
Conditions:
Lipid Metabolism Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The present research protocol will analyze whether a short-term modification (one week) of dietary habits would have an impact on the postprandial metabolism of dietary fatty acids and on their uptake...
Eligibility Criteria
Inclusion
- Healthy subjects: subjects with normal glucose tolerance determined according to an oral glucose tolerance test and with a BMI above 25 kg/m2 without first degree of familial history of type 2 diabetes (parents, siblings).
Exclusion
- overt cardiovascular disease as assessed by medical history, physical exam, and abnormal ECG
- treatment with a fibrate, thiazolidinedione, beta-blocker or other drug known to affect lipid or carbohydrate metabolism (except statins, metformin, and other antihypertensive agents that can be safely interrupted)
- presence of liver or renal disease, uncontrolled thyroid disorder, previous pancreatitis, bleeding disorder, or other major illness
- smoking (\>1 cigarette/day) and/or consumption of \>2 alcoholic beverages per day
- prior history or current fasting plasma cholesterol level \> 7 mmol/l or fasting TG \> 5 mmol/l
- any other contraindication to temporarily interrupt current meds for lipids or hypertension
- being pregnant
- not be barren
Key Trial Info
Start Date :
April 10 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 2 2019
Estimated Enrollment :
14 Patients enrolled
Trial Details
Trial ID
NCT04088344
Start Date
April 10 2013
End Date
July 2 2019
Last Update
September 12 2019
Active Locations (1)
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1
Centre de recherche du CHUS
Sherbrooke, Quebec, Canada, J1H 5N4