Status:
COMPLETED
The Effect of Momordica Charantia Supplementation on Blood Glucose Levels
Lead Sponsor:
Wageningen University and Research
Conditions:
Glucose Intolerance
Eligibility:
All Genders
50-75 years
Phase:
NA
Brief Summary
The study is a randomized, cross-over, double blind, controlled trial in which study participants will receive two 4-week interventions with a washout period of 4 weeks between interventions. Study su...
Detailed Description
Bitter gourd (BG) (Momordica charantia), is a highly nutritive vegetable from the cucumber family. The objective is to assess the impact of 4-week BG supplementation on blood glucose levels and glucos...
Eligibility Criteria
Inclusion
- age 50-75yrs
- BMI \>25 kg/m2
- Having veins suitable for blood sampling via a catheter
- Having one or more of the following criteria:
- HbA1c \> 5.7%
- fasting glucose \>5.6mmol/L
- two-hour glucose levels \>7.8 mmol/L on the 75-g oral glucose tolerance test .
Exclusion
- History of gastro-intestinal surgery or having (serious) gastro-intestinal complaints
- History of liver dysfunction (cirrhosis, hepatitis) or liver surgery
- Kidney dysfunction (self-reported)
- Use of medication/supplements that may influence the study results, such as medicines known to interfere with glucose homeostasis.
- Anaemia (Hb values \<7.5 for women and \<8.5 for men)
- Reported slimming, medically prescribed or other extreme diets
- Reported weight loss or weight gain of \> 5 kg in the month prior to pre-study screening
- Not willing to give up blood donation during the study
- Current smokers
- Alcohol intake ≥4 glasses of alcoholic beverages per day
- Abuse of illicit drugs
- Food allergies for products that we use in the study
- Participation in another clinical trial at the same time
- Being an employee of the Food, Health \& Consumer Research group of Wageningen Food \& Biobased Research or dept. human nutrition and health of Wageningen University.
Key Trial Info
Start Date :
September 17 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 25 2019
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT04090788
Start Date
September 17 2019
End Date
December 25 2019
Last Update
October 12 2020
Active Locations (1)
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1
Stichting Wageningen Research
Wageningen, Gelderland, Netherlands, 6708 WG