Status:
COMPLETED
IntelliCycleTM 2.0 Improved Patient-ventilator Asynchrony During PSV
Lead Sponsor:
Southeast University, China
Conditions:
Automatic Adjustmen of Inspiratory Triger and Cycling-off
Eligibility:
All Genders
18-85 years
Phase:
NA
Brief Summary
Pressure Support Ventilation use Expiratory triggering sensitivity (Esense) to transfer inspiration to expiration, the value of Esense is fixed. That may lead to asynchrony between humans and ventilat...
Detailed Description
This is a physiological cross-over study. Enrolled patient with different baseline respiratory mechanics, for example ARDS patients with low compliance, COPD patient with high airway resistance and po...
Eligibility Criteria
Inclusion
- Postoperation patients
- receiving invasive mechanical ventilation due to operation
- abdominal surgery, orthopedic surgery or gynecological surgery
- without respiratory system Comorbidity
- able to sustain PSV more than 1 h with inspiratory support ≤ 15 cmH2O.
- COPD and ARDS patients
- receiving invasive mechanical ventilation due to acute respiratory failure
- able to sustain PSV more than 1 h with inspiratory support ≤ 15 cmH2O.
Exclusion
- age \< 18 or \>85 years,
- tracheostomy at time of inclusion,
- contra-indication for nasogastric tube insertion (e.g. history of esophageal varices, gastro-esophageal surgery in the previous 12 months or gastro-esophageal bleeding in the previous 7 days, INR ratio \> 1.5 , APTT \> 44 s, history of leukemia),
- neuromuscular disease affecting spontaneous breathing (e.g. history of acute central or peripheral nervous system disorder or neuromuscular disease with irregular spontaneous rhythm),
- hemodynamic unstable (heart rate \> 140 beats/min, vasopressors required with ≥ 5 μg.kg-1.min-1 dopamine/ dobutamine, or ≥ 0.2 μg.kg-1.min-1 norepinephrine),
- sedation level Richmond Agitation-Sedation Scale (RASS) ≤ -2 or ≥ 2,
- lack of informed consent and patients included in other intervention study.
Key Trial Info
Start Date :
September 18 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2019
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT04091269
Start Date
September 18 2019
End Date
December 31 2019
Last Update
July 28 2021
Active Locations (1)
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1
Ling Liu
Nanjing, Jiangsu, China, 210009